Targeting Pathologic Cells to Preserve Biological Youth (Dr. Marco Quarta, Rubedo Life Sciences)

<p>Dr. Marco Quarta, CEO and Co-founder of Rubedo Life Sciences, joins Chris on today’s episode to discuss his company’s strategy of targeting pathologic cells to develop therapeutics for chronic degenerative conditions. The conversation covers the evolving definition of senescence and the challenges of identifying and classifying pathologic cells, which vary across different tissues and indications. Marco also announces the upcoming Senotherapeutic Summit in November, which will bring together stakeholders from different fields to advance therapeutic research.&nbsp;</p><p>Marco and Chris also review Rubedo Life Sciences' clinical development approach: targeting the aging process with the goal of helping healthy stem and immune cells to repair. They then go on to discuss the funding and work required for the selection and nomination of a lead candidate for a project, the importance of having access to primary clinical samples to test efficacy, and the subsequent steps of the grant awarding process. The conversation then turns to the value of having multiple programs running simultaneously.&nbsp;</p><p>Tune in today to learn more about&nbsp; the ‘sneaky’ process of senescence that accelerates aging, the toxicity of these rare cells and the development of small molecules that can target them, the complexities of developing new therapies, and the value of having a robust pipeline of programs to advance therapeutic R&amp;D.</p><p><strong>The Finer Details:</strong></p><ul><li>Defining pathological cells and their role in chronic degenerative conditions</li><li>Identifying, classifying, and targeting senescent cells</li><li>The need for a focused effort in identifying specific targets for therapeutics</li><li>The evolution of the definition of senescence and the existence of multiple types of senescent cells</li><li>The Senotherapeutic Summit in November and its goal of advancing the field of therapeutics</li><li>Running multiple programs simultaneously</li><li>The upcoming event in Saudi Arabia aimed at accelerating