PubReading [329] - The immune suppressive tumor microenvironment in multiple myeloma- The contribution of myeloid-derived suppressor cells - C. Giannotta, F. Autino and M. Massaia

<strong>Myeloid derived suppressors cells</strong> (MDSC) play major roles in regulating <strong>immune homeostasis</strong> and immune responses in many conditions, including cancer. MDSC interact with cancer cells within the <strong>tumor microenvironment</strong> (TME) with direct and indirect mechanisms: production of soluble factors and cytokines, expression of surface inhibitory molecules, metabolic rewiring and exosome release. The two-way relationship between MDSC and tumor cells results in immune evasion and cancer outgrowth. In <strong>multiple myeloma</strong> (MM), <strong>MDSC</strong> play a major role in creating protumoral TME conditions. In this minireview, we will discuss the interplay between MDSC and MM TME and the possible strategies to target MDSC.<em>doi: 10.3389/fimmu.2022.1102471 - 2023</em>