Podcast 767: Transaminitis and Rhabdomyolysis

<p><strong>Contributor: Sam Killian, MD</strong></p> <p><strong>Educational Pearls:</strong></p> <ul> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Transaminitis refers to the elevation of transaminases, enzymes of the liver (AST and ALT)</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Elevation of ALT is relatively specific to the liver, but AST is found in more organs than the liver including the muscle</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">If AST is significantly greater than ALT, consider a musculoskeletal origin such as rhabdomyolysis</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Transaminitis is not always a liver specific issue</span></li> </ul> <p><strong>References</strong></p> <p><span style="font-weight: 400;">Lala V, Goyal A, Minter DA. Liver Function Tests. [Updated 2021 Aug 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482489/</span></p> <p><span style="font-weight: 400;">Lim AK. Abnormal liver function tests associated with severe rhabdomyolysis. World J Gastroenterol. 2020;26(10):1020-1028. doi:10.3748/wjg.v26.i10.1020</span></p> <p><span style="font-weight: 400;">Jo KM, Heo NY, Park SH, et al. Serum Aminotransferase Level in Rhabdomyolysis according to Concurrent Liver Disease. Korean J Gastroenterol. 2019;74(4):205-211. doi:10.4166/kjg.2019.74.4.205</span></p> <p><em><span style="font-weight: 400;">Summarized by John Spartz, MS4 | Edited by Erik Verzemnieks, MD</span></em></p> <p> </p> <p><span style="font-weight: 400;">The Emergency Medical Minute is excited to announce that we are now offering</span> <em><span style="font-weight: 400;">AMA PRA Category 1 credits™</span></em> <span style="font-weight: 400;">via online course modules. To access these and for more information, visit our website at</span> <a href= "https://emergencymedi