Epigenetic Reprogramming Therapies to Extend Healthspan (Dr. Jacob Kimmel, Head of Research, NewLimit)

<p>Jacob Kimball is the Head of Research and co-founder of NewLimit, a company aiming to develop epigenetic reprogramming therapies to treat age-related diseases and extend human healthspan.</p><p>In this episode, Chris and Jacob have an in-depth discussion about NewLimit’s mission and approach. They explore how NewLimit is leveraging epigenetics and machine learning to search for new ways to reverse cell aging without changing cell identity. NewLimit is systematically testing combinations of biological factors that can reprogram cell age, using both biological experimentation and computational modeling at scale, and Jacob shares insights into the cutting-edge science and technology behind this work: how functional genomics allows NewLimit to run hundreds to thousands of experiments in a single dish, how machine learning is used in their research, and the challenges of translating epigenetic reprogramming from the lab to the clinic.&nbsp;</p><p>Listeners will gain a deeper understanding of the promise of epigenetic reprogramming to revolutionize how we treat aging and age-related disease.&nbsp;</p><p><strong>The Finer Details:</strong></p><ul><li>Epigenetics as a regulator of gene expression in cell differentiation and aging</li><li>NewLimit’s mission and approach to tackling the challenges in aging research through epigenetic reprogramming</li><li>The potential for age reversal built into our biology</li><li>How NewLimit is using machine learning and biological experimentation in combination to generate new hypotheses and discoveries</li><li>The potential for epigenetic reprogramming to improve the function of the aging immune system The biggest challenges in translating these discoveries to medicines, including delivery, pharmacokinetics, and ensuring safe and durable effects</li><li>A vision for how rejuvenation biotech could transform health and society in the coming decades if key breakthroughs are made</li></ul><br/><p><strong>Quotes:</strong></p><p>"Epigenetics is this layer of regulation that tells your c