TWiV 879: Indolent, resistant, and losing our TMPRSS

<p>TWiV reviews the emergence of remdesivir-resistant SARS-CoV-2 during treatment of a persistently infected immunocompromised patient, and how altered TMPRSS2 utilization by the Omicron variant influences infectivity and fusion.</p> <p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello</a>, <a href="http://alandove.com/">Alan Dove</a>, <a href="http://mgm.ufl.edu/profile/condit-rich/">Rich Condit</a>, <a href="https://sites.google.com/a/umich.edu/spindler-lab/">Kathy Spindler</a>, and <a href= "http://twitter.com/bioprofbarker">Brianne Barker</a></p> <p>Subscribe (free): <a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065">Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, <a href="http://eepurl.com/Gcw59">email</a></p> <p>Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV!</p> <h3 id="links-for-this-episode"><strong>Links for this episode</strong></h3> <ul> <li><a href="https://asv.org/asv2022/">ASV 2022</a></li> <li>Emergence of <a href= "https://www.nature.com/articles/s41467-022-29104-y">remdesivir resistance</a> (Nature Comm)</li> <li>How to stall a copy machine (<a href= "https://www.microbe.tv/twiv/twiv-819/">TWiV 819</a>)</li> <li>Omicron altered <a href= "https://www.nature.com/articles/s41586-022-04474-x">TMPRSS2 usage</a> (Nature)</li> <li>Timestamps by <a href= "http://www.twitter.com/jrrmicro">Jolene</a>. Thanks!</li> </ul> <h3 id="weekly-picks-1-34-06">Weekly Picks</h3> <p><strong>Brianne</strong> – <a href="https://nsurp.org/">NSURP 2022</a><br /> <strong>Kathy</strong> – <a href="https://jobs.asv.org/">Virology Jobs</a><br /> <strong>Rich</strong> – <a href= "https://www.ncausa.org/about-coffee/10-steps-from-seed-to-cup">10 Steps from Seed to Cup</a> (<a href= "htt