TWiV 860: Evading a Toll on the road to RNA vaccines

<p>TWiV reviews a seminal paper showing that chemically modified bases in RNAs suppress recognition by Toll-like receptors, a finding that that was essential for the development of COVID-19 mRNA vaccines.</p> <p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello</a>, <a href="http://trichinella.org/">Dickson Despommier</a>, <a href= "http://mgm.ufl.edu/profile/condit-rich/">Rich Condit</a>, and <a href="https://sites.google.com/a/umich.edu/spindler-lab/">Kathy Spindler</a></p> <p>Subscribe (free): <a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065">Apple Podcasts</a>, <a href= "https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, <a href="http://eepurl.com/Gcw59">email</a></p> <p>Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV!</p> <h3><strong>Links for this episode</strong></h3> <ul> <li>Vaccine Town Hall (<a href= "http://asv.org/education">ASV</a>)</li> <li>Columbia University BSL-3 <a href= "https://opportunities.columbia.edu/en-us/job/520765/assistant-manager-hcl-bsl3"> Manager position</a></li> <li><a href= "https://www.cell.com/immunity/fulltext/S1074-7613(05)00211-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761305002116%3Fshowall%3Dtrue"> RNA modifications</a> suppress innate recognition (Immunity)</li> <li>Critical contribution of <a href= "https://www.frontiersin.org/articles/10.3389/fcell.2021.789427/full"> pseudouridine</a> (Front Cell Dev Biol)</li> <li>Rich Condit <a href= "https://youtu.be/Jud3PvP7erY">reminisces</a> (YouTube)</li> <li><a href="https://www.microbe.tv/twiv/twiv-860-letters/">Letters read</a> on TWiV 860</li> <li>Timestamps by <a href= "http://www.twitter.com/jrrmicro">Jolene</a>. Thanks!</li> </ul> <h3>Weekly Picks</h3> <p><strong>Dickson -</strong