TWiV 843: COVID-19 clinical update #93 with Dr. Daniel Griffin

<p>In COVID-19 clinical update #93, Dr. Griffin summarizes Omicron fitness, S-gene target failure, monoclonal efficacy against Omicron, vaccination, monoclonals, and disease in children, persistence of memory B cells in the elderly, infection and vaccine induced immunity, protection against severe illness and death by a third mRNA vaccine dose, high flow oxygen versus intubation, and therapeutic anticoagulation.</p> <p>Hosts: <a href="http://parasiteswithoutborders.com/">Daniel Griffin</a> and <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello</a></p> <p>Subscribe (free): <a href= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784">iTunes</a>, <a href="https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, <a href="http://eepurl.com/Gcw59">email</a></p> <p>Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV!</p> <h3><strong>Links for this episode</strong></h3> <ul> <li>Variant <a href= "https://covid.cdc.gov/covid-data-tracker/#variant-proportions">updates</a> (CDC)</li> <li>List of diagnostic kits (Global Fund, <a href= "https://www.theglobalfund.org/media/9629/covid19_diagnosticproducts_list_en.pdf"> pdf</a>)</li> <li>B1.1.529 escapes <a href= "https://www.biorxiv.org/content/10.1101/2021.12.07.470392v1">most antibodies</a> (bioRxiv)</li> <li>mRNA vaccine <a href= "https://www.medrxiv.org/content/10.1101/2021.12.14.21267769v1?rss=1%22"> third dose and Omicron</a> (medRxiv)</li> <li>Outpatient strategies <a href= "https://www.aap.org/en/pages/2019-novel-coronavirus-covid-19-infections/clinical-guidance/outpatient-covid-19-management-strategies-in-children-and-adolescents/"> children and adolescents</a> (AAP)</li> <li><a href="https://pubmed.ncbi.nlm.nih.gov/34843448/">Memory B cells persist</a> in elderly (J Clin Invest)</li> <li><a href="https://www.nejm.org/doi/10.1056/NEJMoa2115926">mRNA booster effect</a>