TWiV 815: MIS-C with Moshe Arditi and Ivet Bahar

<p>Moshe and Ivet join TWiV to discuss their finding that MIS-C is a consequence of a superantigen in the spike protein of SARS-CoV-2 that causes activation of a skewed population of T cell receptor bearing lymphocytes, leading to hyperinflammation.</p> <p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello</a>, <a href="http://www.trichinella.org/">Dickson Despommier</a>, <a href= "http://mgm.ufl.edu/profile/condit-rich/">Rich Condi</a><a href= "http://enterovirus.net/">t</a> and <a href= "https://sites.google.com/a/umich.edu/spindler-lab/">Kathy Spindler</a></p> <p>Guests: <a href= "https://www.cedars-sinai.edu/research/labs/arditi.html">Moshe Arditi</a> and <a href= "https://www.ccbb.pitt.edu/Faculty/bahar/">Ivet Behar</a></p> <p>Subscribe (free): <a href= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784">iTunes</a>, <a href="https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, <a href="http://eepurl.com/Gcw59">email</a></p> <p>Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV!</p> <h3><strong>Links for this episode</strong></h3> <ul> <li>MIS-C in <a href="https://pubmed.ncbi.nlm.nih.gov/33085853/">US children</a> (NEJM)</li> <li><a href= "https://www.pnas.org/content/117/41/25254.long">Superantigen in spike</a> and T cell skewing in MIS-C (PNAS)</li> <li>MIS-C mimics <a href= "https://www.jacionline.org/article/S0091-6749(20)31414-7/fulltext"> toxic shock syndrome</a> (J Allergy Clin Immunol)</li> <li>Antibody against bacterial superantigen <a href= "https://www.cell.com/structure/fulltext/S0969-2126(21)00121-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0969212621001210%3Fshowall%3Dtrue"> blocks SARS-CoV-2 entry</a> (Structure)</li> <li><a href="https://www.jci.org/articles/view/151520">Autoimmune signature</a> of MIS-C in children (J Clin Invest)</li> <li><a href="http