TWiV 751: Sputnik spat and furin in ferrets

<p>TWiV examines the claim by Brazil’s ANVISA that the Sputnik vaccine contains replication-competent adenovirus, and a role for the furin cleavage site in SARS-CoV-2 spike for efficient reproduction in the respiratory tract, evasion of antiviral IFITM proteins, and transmission in ferrets.</p> <p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello</a>, <a href= "http://www.mgm.ufl.edu/faculty/faculty-home-pages/condit-richard-c/"> Rich Condit</a>, and <a href= "https://sites.google.com/a/umich.edu/spindler-lab/">Kathy Spindler</a></p> <p>Subscribe (free): <a href= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784">iTunes</a>, <a href="https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, <a href="http://eepurl.com/Gcw59">email</a></p> <p>Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV!</p> <h3><strong>Links for this episode</strong></h3> <ul> <li>ASV <a href="https://asv.org/Education/">vaccine town halls</a></li> <li><a href= "https://blogs.sciencemag.org/pipeline/archives/2021/04/28/brazil-rejects-the-gamaleya-vaccine"> Brazil rejects</a> Gamaleya vaccine (Sci Transl Med)</li> <li>Russian <a href= "https://blogs.sciencemag.org/pipeline/archives/2021/04/28/russian-vaccine-behavior"> vaccine behavior</a> (Sci Transl Med)</li> <li>Is Gamaleya vaccine <a href= "https://www.sciencemag.org/news/2021/04/russias-covid-19-vaccine-safe-brazils-veto-sputnik-v-sparks-lawsuit-threat-and"> safe</a>? (Science)</li> <li><a href= "https://www.nature.com/articles/s41564-021-00908-w">Furin cleavage site</a> in replication and transmission (Nat Micro)</li> <li>Furin site loss <a href= "https://pubmed.ncbi.nlm.nih.gov/33494095/">attenuates pathogenesis</a> (Nature)</li> <li>Timestamps by <a href= "http://www.twitter.com/jrrmicro">Jolene</a>. Thanks!</li> </ul> <h3>Weekly Picks</h3> <p><strong>Rich</strong> – <a href=