TWiV 734: Weiss hath no furin like a virus scorned

<p>Susan Weiss returns to TWiV to discuss coronavirus entry into cells and the role of spike protein cleavage by proteases, why lab escaped hypotheses for SARS-CoV-2 are unlikely, and modulation of innate immune responses during infection.</p> <p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello,</a> <a href= "http://www.mgm.ufl.edu/faculty/faculty-home-pages/condit-richard-c/"> Rich Condit</a>, <a href="http://www.alandove.com/">Alan Dove</a>, <a href="http://twitter.com/bioprofbarker">Brianne Barker</a>, and <a href="http://www.enterovirus.net/">Amy Rosenfeld</a></p> <p>Guest: <a href= "https://www.med.upenn.edu/apps/faculty/index.php/g20001882/p11346"> Susan Weiss</a></p> <p>Subscribe (free): <a href= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784">iTunes</a>, <a href="https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, <a href="http://eepurl.com/Gcw59">email</a></p> <p>Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV!</p> <h3><strong>Links for this episode</strong></h3> <ul> <li>CoV <a href= "https://pubmed.ncbi.nlm.nih.gov/20369302/">pathogenesis</a> in CNS (J Neuro Pharm)</li> <li>SARS-CoV-2 induces <a href= "https://pubmed.ncbi.nlm.nih.gov/32995797/">dsRNA-mediated</a> innate responses (bioRxiv)</li> <li>Screen of <a href= "https://pubmed.ncbi.nlm.nih.gov/32817221/">FDA-approved</a> drugs (J Viral)</li> <li><a href="https://www.microbe.tv/twiv/twiv-731-letters/">Letters read</a> on TWiV 735</li> <li>Timestamps by <a href= "http://www.twitter.com/jrrmicro">Jolene</a>. Thanks!</li> </ul> <h3>Weekly Picks</h3> <p><strong>Brianne</strong> – <a href= "https://www.tiktok.com/@hotvickkrishna/video/6937457241968643334?is_copy_url=1&is_from_webapp=v1"> Tiktok of How mRNA Vaccines Work</a><br /> <strong>Alan</strong> – <a href= "https://www.netflix.com/title/80100172">Dark</a><br /> <strong>Rich<