The Role of Blimp-1 in Immune-Cell Differentiation (Erna Magnúsdóttir)

<p class="md-end-block md-p">In this episode of the Epigenetics Podcast, we caught up with Erna Magnúsdóttir from the University of Iceland to talk about her work on the role of Blimp-1 in immune-cell differentiation.</p> <p class="md-end-block md-p">The Magnúsdóttir Lab is interested in how the mammalian genome is interpreted in a context dependent manner, leading to different cellular states, by using mouse primordial germ cells as well as mouse and human B-cells as model systems. More specifically, the team is interested in the Transcription Factor Blimp-1 and its effect on immune cell differentiation. Next to its function in immune cells, Blimp-1 also plays a role in Waldenström’s macroglobulinemia. The lab hopes to reveal the intricacies in disease progression and alteration in cellular states to increasingly aggressive tumor behavior.</p> <p class="md-end-block md-p"> </p> <p class="md-end-block md-p">References</p> <ul class="ul-list"><li class="md-list-item"> <p class="md-end-block md-p">Magnúsdóttir, E., Dietmann, S., Murakami, K. et al. A tripartite transcription factor network regulates primordial germ cell specification in mice. Nat Cell Biol 15, 905–915 (2013). <a href='https://doi.org/10.1038/ncb2798'>https://doi.org/10.1038/ncb2798</a></p> </li> <li class="md-list-item"> <p class="md-end-block md-p">Anderson, K.J., Ósvaldsdóttir, Á.B., Atzinger, B. et al. The BLIMP1—EZH2 nexus in a non-Hodgkin lymphoma. Oncogene 39, 5138–5151 (2020). <a href='https://doi.org/10.1038/s41388-020-1347-8'>https://doi.org/10.1038/s41388-020-1347-8</a></p> <p class="md-end-block md-p"> </p> </li> </ul> <p class="md-end-block md-p">Related Episodes</p> <ul class="ul-list"><li class="md-list-item"> <p class="md-end-block md-p"><a href='https://www.activemotif.com/podcasts#ken-zaret'>Pioneer Transcription Factors and Their Influence on Chromatin Structure (Ken Zaret)</a></p> </li> <li class="md-list-item"> <p class="md-end-block md-p"><a href='https://www.activemotif.com/podcasts#deborah-bourchis'>DNA Methylation and Mamma