PubReading [41] - Apoptosis: A Target for Anticancer Therapy - C. M. Pfeffer and A. T. K. Singh

<p><strong>Apoptosis</strong>, the cell’s natural mechanism for death, is a promising target for anticancer therapy. Both the <strong>intrinsic </strong>and <strong>extrinsic pathways</strong> use <strong>caspases</strong> to carry out apoptosis through the cleavage of hundreds of proteins. In cancer, the apoptotic pathway is typically inhibited through a wide variety of means including overexpression of antiapoptotic proteins and under-expression of proapoptotic proteins. Many of these changes cause intrinsic resistance to the most common <strong>anticancer therapy</strong>, chemotherapy. Promising new anticancer therapies are <strong>plant-derived compounds</strong> that exhibit anticancer activity through activating the apoptotic pathway. doi:10.3390/ijms19020448 - 2018</p>