PubReading [213] - Stabilisation of self-assembled DNA crystals by triplex-directed photo-cross-linking - H. Abdallah, N. Seeman et al.

<p>The <strong>tensegrity triangle</strong> is a robust DNA motif that can self-assemble to generate macroscopic three-dimensional crystals. However, the stability of these crystals is dependent on the high ionic conditions used for crystal growth. Here we demonstrate that a triplex-forming oligonucleotide can be used to direct the specific intercalation, and subsequent photo-cross-linking, of 4,5′,8-trimethylpsoralen to single or multiple loci within or between the tiles of the crystal. Cross-linking between the tiles of the crystal improves their <strong>thermal stability</strong>. Such an approach is likely to facilitate the removal of crystals from their mother liquor and may prove useful for applications that require greater <strong>crystal stability</strong>.</p><p><em>DOI: 10.1039/c6cc03695c - 2016</em></p>