Podcast 777: Grass, Weed, and Ancient Rome

<p><strong>Contributor: Chris Holmes, MD</strong></p> <p><strong>Educational Pearls:</strong></p> <ul> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Antiemetics were used in ancient Rome to help with sea-sickness and included toxic substances such as wine and wormwood and white hellborn</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">The first antihistamine used for nausea, dramamine, was introduced in 1947 for motion sickness</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">After this chlorpromazine, prochlorperazine, and promethazine came about in the 1950s and 1960s</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Cannabis, colloquially referred to as weed, isolates like THC used in the 1970s to help with chemotherapy-induced</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">After this in the 1980s, ondansetron and metoclopramide were introduced for more severe chemotherapy-induced nausea</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Lastly, NK-1 inhibitors were introduced to treat nausea</span></li> </ul> <p><strong>References</strong></p> <p><span style="font-weight: 400;">Sanger GJ, Andrews PLR. A History of Drug Discovery for Treatment of Nausea and Vomiting and the Implications for Future Research. Front Pharmacol. 2018;9:913. Published 2018 Sep 4. doi:10.3389/fphar.2018.00913</span></p> <p><em><span style="font-weight: 400;">Summarized by John Spartz, MS4 | Edited by Erik Verzemnieks, MD</span></em></p> <p> </p> <p><span style="font-weight: 400;">The Emergency Medical Minute is excited to announce that we are now offering</span> <em><span style="font-weight: 400;">AMA PRA Category 1 credits™</span></em> <span style="font-weight: 400;">via online course modules. To access these and for more information, visit our website at</span> <a href= "https://emergencymedicalminut