Podcast 691: TXA in Head Bleeds

<p><strong>Contributor: Ricky Dhaliwal, MD</strong></p> <p><strong>Educational Pearls:</strong></p> <ul> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">CRASH 3 Trial looked at over 12,000 patients with traumatic intracranial bleeds, randomizing patients to a therapy with TXA or standard of care without TXA</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Dosing was 1 gram over 10 min for loading dose and then an infusion of 1 gram over 8 hours</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Found Improvement in survival and neurologic outcomes when patient received TXA within 3 hours</span></li> </ul> <p><strong>References</strong></p> <p><span style="font-weight: 400;">CRASH-3 trial collaborators. Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial [published correction appears in Lancet. 2019 Nov 9;394(10210):1712]. Lancet. 2019;394(10210):1713-1723. doi:10.1016/S0140-6736(19)32233-0</span></p> <p> </p> <p><span style="font-weight: 400;">The Emergency Medical Minute is excited to announce that we are now offering</span> <em><span style="font-weight: 400;">AMA PRA Category 1 credits™</span></em> <span style="font-weight: 400;">via online course modules. To access these and for more information, visit our website at</span> <a href= "http://www.emergencymedicalminute.org/cme-courses"><span style= "font-weight: 400;">www.emergencymedicalminute.org/cme-courses/</span></a> <span style="font-weight: 400;">and create an account. </span></p> <p><a href= "https://www.paypal.com/donate?token=6bIZ91UwjZALMiRLAEcQYYPHyLILwbivQwgtGl3JzaB6oGAQK1B2nrGSGvrS-g7zJApXzVlWIO-lmLfB"> <span style="font-weight: 400;">Donate to EMM today!</span></a></p> <p><br /> <br /></p>