Podcast 622: High Altitude Pulmonary Edema (HAPE)

<p><strong>Contributor: Thomas Seibert, MD</strong></p> <p><strong>Educational Pearls:</strong></p> <ul> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">High Altitude Pulmonary Edema (HAPE) typically occurs 2-4 days after arriving at elevation</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Symptoms include:</span></li> <li style="list-style: none; display: inline;"> <ul> <li style="font-weight: 400;" aria-level="2"><span style= "font-weight: 400;">Fatigue</span></li> <li style="font-weight: 400;" aria-level="2"><span style= "font-weight: 400;">Dyspnea</span></li> <li style="font-weight: 400;" aria-level="2"><span style= "font-weight: 400;">Cough</span></li> </ul> </li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Treatment includes:</span></li> <li style="list-style: none; display: inline;"> <ul> <li style="font-weight: 400;" aria-level="2"><span style= "font-weight: 400;">Descent to lower elevation </span></li> <li style="font-weight: 400;" aria-level="2"><span style= "font-weight: 400;">Oxygen supplementation</span></li> <li style="font-weight: 400;" aria-level="2"><span style= "font-weight: 400;">Nifedipine</span></li> </ul> </li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Caused by sympathetic stimulation from hypobaric hypoxic exposure, causing uneven pulmonary vasculature constriction and when paired with a leaky endothelium, pulmonary edema. #science</span></li> </ul> <p><strong>References</strong></p> <p><span style="font-size: 10pt;"><span style= "font-weight: 400;">Swenson ER, Bärtsch P.</span> <a href= "https://pubmed.ncbi.nlm.nih.gov/23720264/"><span style= "font-weight: 400;">High-altitude pulmonary edema.</span></a> <span style="font-weight: 400;">Compr Physiol. 2012 Oct;2(4):2753-73. doi: 10.1002/cphy.c100029. PMID: 23720264.</span></span></p> <p><span style="font-size: 10pt;"><span style= "font-weight: 400;">Johnson NJ, Luks AM.</span> <a href= "https://pubme