Podcast 619: Other Uses for Zyprexa

<p><strong>Contributor: Don Stader, MD</strong></p> <p><strong>Educational Pearls:</strong></p> <ul> <li style="font-weight: 400;"><span style= "font-weight: 400;">Zyprexa (olanzapine) is a second generation antipsychotic with multiple other uses</span></li> <li style="font-weight: 400;"><span style= "font-weight: 400;">Excellent for treating nausea in patients undergoing chemotherapy or with THC hyperemesis syndrome</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Helps with the psychological and emotional aspect of pain</span></li> <li style="font-weight: 400;"><span style= "font-weight: 400;">Effective in treatment of headaches</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Can be given under the tongue</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Fewer incidences of dystonic reactions compared with first generation antipsychotics</span></li> <li style="font-weight: 400;"><span style= "font-weight: 400;">Patients using anti-dopaminergic should not receive antipsychotics because they also work on dopaminergic receptors</span></li> </ul> <p><strong>References</strong></p> <p><span style="font-size: 10pt;"><span style= "font-weight: 400;">Navari RM, Qin R, Ruddy KJ, Liu H, Powell SF, Bajaj M, Dietrich L, Biggs D, Lafky JM, Loprinzi CL.</span> <a href="https://pubmed.ncbi.nlm.nih.gov/?term=zyprexa+nausea"><span style="font-weight: 400;"> Olanzapine for the Prevention of Chemotherapy-Induced Nausea and Vomiting.</span></a> <span style="font-weight: 400;">N Engl J Med. 2016 Jul 14;375(2):134-42. doi: 10.1056/NEJMoa1515725. PMID: 27410922; PMCID: PMC5344450.</span></span></p> <p><span style="font-size: 10pt;"><span style= "font-weight: 400;">Jimenez XF, Sundararajan T, Covington EC.</span> <a href= "https://pubmed.ncbi.nlm.nih.gov/29077621/"><span style= "font-weight: 400;">A Systematic Review of Atypical Antipsychotics in Chronic Pain Management: Olanzapine Demonstrates Potential in Central Sensitization, Fibromyalgia, and Headache/Migr