Podcast 600: Penicillin Allergy?

Victoire🦋

2 min

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Contributor: Aaron Lessen, MD Educational Pearls: <ul> <li style="font-weight: 400;">True allergies to penicillin compared to reported allergies from patients ranges around 10%</li> <li style="font-weight: 400;">Recent study took patients undergoing sensitivity tests and developed the PEN(icillin)-FAST score to address reported penicillin allergies</li> <li style="font-weight: 400;">PEN-FAST has four components for a total score of 0-4:</li> </ul> o F = five years or less since prior reaction. o A = Angioedema/Anaphylaxis. o S = Severe cutaneous reaction (rash). o T = Treatment, did they require treatment for a reaction? <ul> <li style="font-weight: 400;">Patients with a score of 0 had <1% incidence of penicillin allergy</li> <li style="font-weight: 400;">Even a score of 1-2 points had around 5% incidence of a true allergy</li> </ul> References Trubiano JA, Vogrin S, Chua KYL, Bourke J, Yun J, Douglas A, Stone CA, Yu R, Groenendijk L, Holmes NE, Phillips EJ. <a href= "https://pubmed.ncbi.nlm.nih.gov/32176248/">Development and Validation of a Penicillin Allergy Clinical Decision Rule.</a> JAMA Intern Med.

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