Podcast 561:  Give Bup

<p><strong>Contributor: Don Stader, MD</strong></p> <p><strong>Educational Pearls:</strong></p> <ul> <li style="font-weight: 400;"><span style= "font-weight: 400;">Buprenorphine has been shown to decrease morbidity and mortality in opioid use disorder</span></li> <li style="font-weight: 400;"><span style= "font-weight: 400;">Buprenorphine used in naloxone-induced withdrawals can displace naloxone at opioid receptors, leading to reduced withdrawal symptoms and lessen the chance of using after discharge</span></li> <li style="font-weight: 400;"><span style= "font-weight: 400;">Patients in acute withdrawal due to naloxone after an overdose should be given Buprenorphine. Data shows that withholding Buprenorphine leads to increased mortality rates of 5% within the following month, and 10% in the following year.</span></li> </ul> <p><strong>References</strong></p> <ol> <li><span style="font-weight: 400;">Herring, Andrew. “Emergency Department Medication-Assisted Treatment of Opioid Addiction.” Chcf.org, Aug. 2016, www.chcf.org/wp-content/uploads/2017/12/PDF-EDMATOpioidProtocols.pdf.</span></li> <li><span style="font-weight: 400;">D.H. Cisewski et al. Approach to buprenorphine use for opioid withdrawal treatment in the emergency setting. American Journal of Emergency Medicine 37 (2019) 143–150</span></li> </ol> <p><em><span style="font-weight: 400;"> </span></em></p> <p><em><span style="font-weight: 400;">Summarized by Jackson Roos, MS4 | Edited by Erik Verzemnieks, MD</span></em></p> <p><br /> <br /></p>