Patient Recruitment Failure in Clinical Trials

<p><span style="font-weight: 400;">This podcast episode highlights the top reasons for patient recruitment failure in clinical trials from an investigator perspective.</span></p> <p> </p> <p><span style="font-weight: 400;">The podcast episode will help you understand how Sponsor and CRO personnel including software vendors can best support investigators meet or exceed their patient recruitment. </span></p> <p> </p> <p><span style="font-weight: 400;">The goal is to bring more awareness on how to prevent patient recruitment failure and complete enrollment as planned.</span></p> <p> </p> <ol> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Initial funding insufficient to reimburse recruiting staff/sites</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Context-specific logistic obstacles (e.g., urgent transfers from intensive care, different treatment availabilities at different centers or on weekends)</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Lack of methodological/logistical support (e.g., from contract research organization or clinical trial unit)</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Prejudice against effectiveness of trial interventions </span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">New evidence from other study about effectiveness of trial interventions</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Administrative burden/time constraints </span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Lack of eligible participants - Overestimated prevalence (mostly reported as overly narrow eligibility criteria)</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Concurrent competing trials</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">High burden (e.g