Episode 288: Pharmacology 101: Antimetabolites

<div class="SCXW215697749 BCX0"> <div class="OutlineElement Ltr SCXW215697749 BCX0"> <p class="Paragraph SCXW215697749 BCX0"><span class= "TextRun SCXW215697749 BCX0" lang="EN-US" xml:lang="EN-US" data-contrast="auto"><span class= "NormalTextRun SCXW215697749 BCX0">“</span><span class= "NormalTextRun SCXW215697749 BCX0">I think that there</span> <span class="NormalTextRun SCXW215697749 BCX0">are certain agents that are so foundational in some diseases that they will remain</span><span class= "NormalTextRun SCXW215697749 BCX0">.</span> <span class= "NormalTextRun SCXW215697749 BCX0">W</span><span class= "NormalTextRun SCXW215697749 BCX0">hether they</span> <span class= "NormalTextRun SCXW215697749 BCX0">remain</span> <span class= "NormalTextRun SCXW215697749 BCX0">first</span><span class= "NormalTextRun SCXW215697749 BCX0">-</span><span class= "NormalTextRun SCXW215697749 BCX0">line</span><span class= "NormalTextRun SCXW215697749 BCX0">, m</span><span class= "NormalTextRun SCXW215697749 BCX0">aybe not</span><span class= "NormalTextRun SCXW215697749 BCX0">;</span> <span class= "NormalTextRun SCXW215697749 BCX0">m</span><span class= "NormalTextRun SCXW215697749 BCX0">aybe</span> <span class= "NormalTextRun SCXW215697749 BCX0">they</span><span class= "NormalTextRun SCXW215697749 BCX0">’</span><span class= "NormalTextRun SCXW215697749 BCX0">ll</span> <span class= "NormalTextRun SCXW215697749 BCX0">go to</span> <span class= "NormalTextRun SCXW215697749 BCX0">second</span> <span class= "NormalTextRun SCXW215697749 BCX0">line</span> <span class= "NormalTextRun SCXW215697749 BCX0">as we see things evolve with new agents. Some of these drugs have been</span> <span class= "NormalTextRun SCXW215697749 BCX0">very effective</span> <span class="NormalTextRun SCXW215697749 BCX0">in the diseases in which they are used to treat patients.</span> <span class= "NormalTextRun SCXW215697749 BCX0">T</span><span class= "NormalTextRun SCXW215697749 BCX0">here</span><span class= "NormalTextRun SCXW215697749 BCX0">’</span><span class= "Norm