#56 Polygenic risk scores in admixed populations with Bárbara Bitarello

<p>Polygenic risk scores (PRS) rely on the genome-wide association studies (GWAS) to predict the phenotype based on the genotype. However, the prediction accuracy suffers when GWAS from one population are used to calculate PRS within a different population, which is a problem because the majority of the GWAS are done on cohorts of European ancestry.</p> <p>In this episode, <a href="https://bbitarello.github.io/">Bárbara Bitarello</a> helps us understand how PRS work and why they don’t transfer well across populations.</p> <p>Links:</p> <ul> <li><a href="https://www.g3journal.org/content/10/11/4027">Polygenic Scores for Height in Admixed Populations</a> (Bárbara D. Bitarello, Iain Mathieson)</li> <li><a href="https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008624">What is ancestry?</a> (Iain Mathieson, Aylwyn Scally)</li> </ul>