TWiV 829: Antiviral and cytotoxically empowered for COVID-19

<p>A TWiV duo reviews how SARS-CoV-2 attacks the olfactory mucosa but spares the olfactory bulb, vaccination with BNT162b2 induces virus-specific stem cell memory T cells, and development of an oral protease inhibitor for the treatment of COVID-19.</p> <p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello</a> and <a href= "http://twitter.com/bioprofbarker">Brianne Barker</a></p> <p>Subscribe (free): <a href= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784">iTunes</a>, <a href="https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, <a href="http://eepurl.com/Gcw59">email</a></p> <p>Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV!</p> <h3><strong>Links for this episode</strong></h3> <ul> <li>How SARS-CoV-2 attacks <a href= "https://www.sciencedirect.com/science/article/pii/S0092867421012824"> olfactory mucosa</a> (Cell)</li> <li>SARS-CoV-2-specific <a href= "https://www.science.org/doi/10.1126/sciimmunol.abl5344">stem cell memory T cells</a> after mRNA vaccine (Sci Immunol)</li> <li>Oral SARS-CoV-2 <a href= "https://pubmed.ncbi.nlm.nih.gov/34726479/">protease inhibitor</a> (Science)</li> <li><a href= "https://www.pfizer.com/news/press-release/press-release-detail/pfizers-novel-covid-19-oral-antiviral-treatment-candidate"> Paxlovid phase 2/3 trial</a> preliminary results (Pfizer)</li> <li><a href="https://www.microbe.tv/twiv/twiv-829-letters/">Letters read</a> on TWiV 829</li> <li>Timestamps by <a href= "http://www.twitter.com/jrrmicro">Jolene</a>. Thanks!</li> </ul> <h3>Weekly Picks</h3> <p><strong>Brianne</strong> – <a href= "https://www.youtube.com/watch?v=8nD6Q9X0SFw">Coronavirus Neutralizing Antibodies and mRNA Vaccine Video</a><br /> <strong>Vincent</strong> – <a href= "https://www.nature.com/articles/248701a0">MHC restriction of cytotoxic T cell lysis</a> (<a href= "https://www.nobelprize.org/