PubReading [293] - The Nuclear Factor Kappa B (NF-kB) signaling in cancer development and immune diseases - M. Zinatizadeh, S. Miri et al.

<p>The <strong>nuclear factor kappa B</strong> (NF-kB) family of transcription factors plays an essential role as stressors in the cellular environment, and controls the expression of important <strong>regulatory genes</strong> such as immunity, inflammation, death, and cell proliferation. NF-kB protein is located in the cytoplasm, and can be activated by various cellular stimuli. There are two pathways for NF-kB activation, as the canonical and non-canonical pathways, which require complex molecular interactions with adapter proteins and phosphorylation and ubiquitinase enzymes. Accordingly, this increases NF-kB translocation in the nucleus and regulates gene expression. In this study, the concepts that emerge in different cellular systems allow the design of <strong>NF-kB </strong>function in humans. This would not only allow the development for rare diseases associated with NF-kB, but would also be used as a source of useful information to eliminate widespread consequences such as <strong>cancer </strong>or inflammatory/immune diseases.</p><p><a href="https://doi.org/10.1016/j.gendis.2020.06.005">https://doi.org/10.1016/j.gendis.2020.06.005</a> - 2020</p>