PubReading [291] - Tumour Cell Secretome in Chemoresistance and Tumour Recurrence - E. Madden, A. Samali et al.

<p><strong>Chemoresistance</strong> is a major factor driving tumour relapse and the high rates of cancer-related deaths. Understanding how cancer cells overcome chemotherapy-induced cell death is critical in promoting patient survival. One emerging mechanism of chemoresistance is the <strong>tumour cell secretome</strong> (TCS), an array of protumorigenic factors released by tumour cells. Chemotherapy exposure can also alter the composition of the TCS, known as therapy-induced TCS, and can promote tumour relapse and the formation of an immunosuppressive <strong>tumour microenvironment</strong> (TME). Here, we outline how the TCS can protect cancer cells from chemotherapy-induced cell death. We also highlight recent evidence describing how therapy-induced TCS can impact <strong>cancer stem cell </strong>(CSC) expansion and tumour-associated immune cells to enable tumour regrowth and antitumour immunity.</p><p><a href="https://doi.org/10.1016/j.trecan.2020.02.020"><em>https://doi.org/10.1016/j.trecan.2020.02.020</em></a><em> - 2020</em></p>