PubReading [286] - Cancer occurrence in Turner syndrome and the effect of sex hormone substitution therapy - M. Viuff, C. Gravholt et al.

<p>Although the overall risk of cancer is not increased in <strong>Turner syndrome</strong>, the pattern of cancer occurrence differs from the general population. We aim to describe the cancer morbidity pattern in Turner syndrome and evaluate the effect of long-term <strong>hormone replacement therapy</strong> (HRT). <em>Design: </em>Nationwide epidemiological study. The lack of one X chromosome might play a role in skin neoplasms, CNS tumors, colon and rectal cancers. The risk of breast cancer is lower than in the general population. Long-term HRT during the <strong>premenopausal</strong> age range seems not to exert a cancerous effect in Turner syndrome. Increased vigilance concerning specific types of cancer in Tuner syndrome harboring a 45,X karyotype is needed.</p><p><a href="https://doi.org/10.1530/EJE-20-0702"><em>https://doi.org/10.1530/EJE-20-0702</em></a><em> - 2021</em></p>